Jose Jalife, MD
Cyrus and Jane Farrehi Professor of Cardiovascular Research. Professor of Internal Medicine and Molecular and Integrative Physiology. Co-director of the U-M Center for Arrhythmia Research
José Jalife, M.D. completed his M.D. at the Universidad Nacional Autónoma de México. After clinical training in Spain, he returned to Mexico to conduct research in cardiovascular pharmacology and physiology at the Universidad Nacional and the National Institute of Cardiology. He moved to the United States to work as a postdoctoral fellow the Upstate Medical Center in Syracuse, NY, and the Masonic Medical Research Laboratory in Utica, NY. He joined the Department of Pharmacology, Upstate Medical University, as a member of the faculty. He was recruited by the University of Michigan to his present position as an endowed professor and co-director of the Center for Arrhythmia Research.
Dr. Jalife enjoys an international reputation as a leader in his field of research, which focuses on bringing sophisticated mathematical and biophysical concepts to increase the understanding of the mechanisms of life-threatening cardiac arrhythmias, from the molecule to the bedside. He and his associates have investigated the molecular mechanisms and nonlinear dynamics of heart rhythm and conduction disturbances. Their studies have provided important insight that has led to reevaluation of classical criteria for the diagnosis of complex arrhythmias, including atrial fibrillation and ventricular fibrillation. Other contributions include studies on the cellular mechanisms of dynamic vagal control of heart rate and atrioventricular conduction and the mechanisms of pacemaker synchronization in the sinoatrial node; non-linear dynamics of excitation and propagation in isolated cardiac tissues; application of video-imaging techniques and the use of transgenic and knockout mice to study wave propagation and spiral wave formation in cardiac muscle; and more recently, the study of the cellular and molecular mechanisms underlying sudden death in inherited arrhythmogenic diseases.
Jalife’s work has led to major advances toward elucidating the molecular and cellular bases of the initiation and propagation of electrical impulses in the heart and the fundamental mechanisms of complex life-threatening arrhythmias and sudden cardiac death. He has published more than 258 original papers and review articles, and has edited/authored thirteen books, including the internationally acclaimed Cardiac Electrophysiology: From Cell to Bedside, now in its fifth edition. Dr. Jalife’s efforts and those of his close associates have been generously supported by RO1 grants from NHLBI, Established Investigator and Scientist Development grants from the American Heart Association, numerous of Grants-in-Aid and fellowships from AHA and the Heart Rhythm Society (formerly NASPE), and two currently active Program Project Grants from the NHLBI. In turn, Dr. Jalife has been a member of the Research Committee A of NHLBI, and has served on the Cardiology Advisory Committee, as a member in the Cardiovascular Study Section, (CVA, 1997-2001) and the more recently established ESTA Study Section, as well as in various site visit committees and the Executive Committee of the Basic Science Council of AHA.
In 2001 Dr. Jalife was awarded the Distinguished Scientist Award of the American College of Cardiology. Other accolades include the Lucian Award for Research in Circulatory Diseases from McGill University, the President’s Award for Research at SUNY Upstate Medical University, the Professor Pierre Rijlant Award from the Académie Royale de Médecine de Belgique in Brussels, Belgium, and the 2002 State University of New York Chancellor’s Award for Excellence in Scholarship and Creative Activities. In 2008 Dr. Jalife was elected Vice-President of the Cardiac Electrophysiology Society.