Joan Greve, PhD
Assistant Professor of Biomedical Engineering
Joan is an MRI physiologist focused on preclinical models in an effort to improve the human condition. She received her BS (U. of Washington) and PhD (Stanford) in bioengineering. Twelve years working at Genentech, Inc. instilled a commitment to translational science and matched passion for the basic science underlying it. She has used MRI to develop the first application of phase-contrast MRI and computational fluid dynamic modeling in rodent models to examine how wall shear stress scales across species, as well as to study peripheral artery disease, vascular endothelial growth factor, and the relationship between angiogenesis and arteriogenesis. Joan has extensive regularity science knowledge, including co-authoring an IND application to the FDA and leading the imaging biomarker strategy for Phase I and II clinical trials. Her published imaging work spans ultrasound, optical, positron emission tomography, and MRI. Having led the preclinical MRI labs at Stanford (3 years) and Genentech (5 years), Joan joined University of Michigan in 2014 and serves as one of two Vice-Chairs for the University of Michigan Institutional Animal Care and Use Committee.
The Greve Lab at Michigan is driven by the biological question. They provide novel answers by developing robust and reproducible preclinical MRI techniques and applying engineering principles. Therapeutically, the Greve Lab is interested in the use of exercise to stimulate intrinsic therapeutic pathways to treat CV disease (leveraging the ‘internal pharmacy’, as described by others). This could include the development of treatments from a better understanding of the molecular pathways induced through beneficial biomechanical stimuli, e.g. wall shear stress. Exercise is already part of the standard-of- care for myocardial infarction, while clinical trials using exercise training have been undertaken for abdominal aortic aneurysm and deep vein thrombosis. This interest also aligns with recent considerations by the Centers for Medicare & Medicaid Services for supervised exercise therapy for patients with peripheral artery disease.
The focus of the Greve Lab is represented by the following areas:
- In vivo measurement of functional outcomes due to structural changes
- Defining, quantifying, monitoring variability in data
- Therapeutic development in preclinical models in support of translation
- The use of aged rodent models to better recapitulate the human condition